One of the most interesting things about Prototype 2 was the fact that for some reason or another the protagonist changed. Instead of playing as Alex Mercer you will be playing as James Heller and in the latest video the developers explain why that is. Because nothing says overpowered enemy like one that you created yourself.
The video explains that James Heller lost everything in his life, including his family. Now he has been infected by Alex Mercer himself and is out for revenge against Alex. Besides the story explanation we also see some pre-alpha footage of the game. It most certainly is pre-alpha because the game isn’t even slated for release until some point in 2012.